ADORA1 抗体 (3rd Intracellular Loop)
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Quick Overview for ADORA1 抗体 (3rd Intracellular Loop) (ABIN7042882)
抗原
See all ADORA1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- 3rd Intracellular Loop, AA 213-229
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原理
- A Rabbit Polyclonal Antibody to Adenosine A1 Receptor
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat,bovine,canis,pig - identical
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产品特性
- Anti-Adenosine A1 Receptor Antibody is directed against human adenosine A1 receptor. Anti-Adenosine A1 Receptor Antibody (ABIN7042882, ABIN7043894 and ABIN7043895) can be used in western blot analysis, immunocytochemical and immunohistochemical applications. It has been designed to recognize adenosine A1R from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KKVSASSGDPQKYYGKE, corresponding to amino acid residues 213-229 of human A1AR
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亚型
- IgG
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anti-Adenosine A1 Receptor (ADORA1) antibody
ADORA1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (AA 225-326) antibodyADORA1 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (AA 153-168), (Extracellular), (Loop 2) antibodyADORA1 适用: 大鼠 WB, IHC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (C-Term) antibodyVerified ADORA1 适用: 人 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (Asp326) antibodyADORA1 适用: 人, 大鼠, 小鼠 WB, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) antibodyADORA1 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 10D12 unconjugated Recombinant Antibody
anti-Adenosine A1 Receptor (ADORA1) (C-Term) antibodyADORA1 适用: 人, 大鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (AA 151-250) antibodyADORA1 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (AA 202-235) antibodyADORA1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A1 Receptor (ADORA1) (Cytoplasmic Domain) antibodyADORA1 适用: 人, 大鼠, 小鼠, Pig, Cow, 猴, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:100
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234623)
Blocking Peptide: (ABIN7234623)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- ADORA1 (Adenosine A1 Receptor (ADORA1))
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别名
- ADORA1
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背景
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Synonyms: ADORA1, A1AR, Adenosine A1R
Description: Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including the brain and heart.1,2 Adenosine exerts its actions via four specific adenosine receptors (also named P1 purinergic receptors): Adenosine A1 Receptor (A1AR), Adenosine A2A Receptor (A2AAR), Adenosine A2B Receptor (A2BAR), and Adenosine A3 Receptor (A3AR). All are integral membrane proteins and are members of the G protein-coupled receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop that is important for binding G proteins.1-3 The adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs.1-3A1AR is widely distributed and has been well characterized. High expression of A1AR is found in the brain (mainly in the cortex, cerebellum, and hippocampus), dorsal horn of the spinal cord, adrenal gland, and atria, and to a lower extent in several other tissues including adipose tissue, the colon, and kidney.2,4A1AR modulates the activity of several ion channels. Activation of A1AR (by adenosine, its major agonist) inhibits N-type Ca2+ channels via a voltage-dependent, pertussis toxin (PTX)-sensitive pathway in neurons of the rat major pelvic ganglia (MPG).5Since A1AR is the most prominent adenosine receptor in adipocytes, it has become a natural target for research on obesity, which is a major health problem.6,7 A possible role in cell proliferation and carcinogenesis has also been suggested for A1AR.8-10
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基因ID
- 134
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NCBI登录号
- NM_000674
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UniProt
- P30542
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途径
- EGFR Signaling Pathway, Negative Regulation of Hormone Secretion, Synaptic Membrane
抗原
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