FLASH 抗体 (AA 1861-1982)
Quick Overview for FLASH 抗体 (AA 1861-1982) (ABIN702220)
抗原
See all FLASH (CASP8AP2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1861-1982
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Dog,Cow,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human FLASH/CASP8AP2
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亚型
- IgG
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anti-CASP8 Associated Protein 2 (CASP8AP2) antibody
CASP8AP2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CASP8 Associated Protein 2 (CASP8AP2) (AA 110-159) antibodyCASP8AP2 适用: 人, 小鼠, 大鼠, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-CASP8 Associated Protein 2 (CASP8AP2) (AA 1733-1982) antibodyCASP8AP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CASP8 Associated Protein 2 (CASP8AP2) (N-Term) antibodyCASP8AP2 适用: 人, 小鼠, 大鼠, 犬, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-CASP8 Associated Protein 2 (CASP8AP2) (N-Term) antibodyCASP8AP2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-CASP8 Associated Protein 2 (CASP8AP2) (C-Term) antibodyCASP8AP2 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))
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别名
- FLASH/CASP8AP2
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背景
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Synonyms: CASP 8 associated protein 2, CASP8 associated protein 2, CASP8AP2, Caspase 8 associated protein 2, CED 4, CED4, FLASH homolog, FLASH homolog RIP 25, FLASH homolog RIP25, FLICE associated huge, FLICE associated huge protein, FLICE-associated huge protein, RIP 25, RIP25, AA387232, D4Ertd659e, mKIAA1315, C8AP2_HUMAN, CASP8-associated protein 2, FLICE-associated huge protein, FLJ11208, KIAA1315, OTTMUSP00000005125, RP23-69G24.1.
Background: FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor, Fas binding adapter FADD, and caspase 8, and plays a regulatory role in Fas mediated apoptosis.
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基因ID
- 9994
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途径
- Chromatin Binding, Positive Regulation of Endopeptidase Activity
抗原
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