FLT3 抗体 (pTyr589, pTyr591)
Quick Overview for FLT3 抗体 (pTyr589, pTyr591) (ABIN7265244)
抗原
See all FLT3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr589, pTyr591
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产品特性
- Phosphorylated antibody
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纯化方法
- Affinity purification
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免疫原
- A synthetic phosphorylated peptide around Y589 & Y591 of human FLT3 (NP_004110.2).
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亚型
- IgG
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应用备注
- WB 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
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别名
- FLT3
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背景
- This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
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分子量
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Observed_MW: 113 kDa
Calculated_MW: 108 kDa/112 kDa
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基因ID
- 2322
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UniProt
- P36888
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途径
- RTK signaling
抗原
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