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Dynactin 1 抗体

This anti-Dynactin 1 antibody (ABIN7259741) is a Rabbit Polyclonal antibody detecting Dynactin 1 in IF. Suitable for Human, Mouse, Rat.
产品编号 ABIN7259741
发货至: 中国

Quick Overview for Dynactin 1 抗体 (ABIN7259741)

抗原

See all Dynactin 1 (DCTN1) 抗体
Dynactin 1 (DCTN1)

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This Dynactin 1 antibody is un-conjugated

应用范围

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Immunofluorescence (IF)
  • 产品特性

    Polyclonal Antibody

    纯化方法

    Affinity purification

    免疫原

    Recombinant fusion protein of human DCTN1 (NP_001128513.1).

    亚型

    IgG
  • 应用备注

    IF 1:20-1:100

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    Dynactin 1 (DCTN1)

    别名

    DCTN1

    背景

    This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

    基因ID

    1639

    UniProt

    Q14203

    途径

    M Phase, ER-Nucleus Signaling
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