Shugoshin 抗体
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北京 101111
Quick Overview for Shugoshin 抗体 (ABIN7258968)
抗原
See all Shugoshin (SGOL1) 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein of human SGOL1 (NP_612493.1).
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亚型
- IgG
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anti-Shugoshin 1 (SGOL1) (AA 1-292) antibody
SGOL1 适用: 人 ELISA, WB, IP 宿主: 小鼠 Monoclonal 3C11 unconjugated
anti-Shugoshin 1 (SGOL1) (AA 260-439) antibodySGOL1 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) antibodySGOL1 适用: Schizosaccharomyces pombe WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (AA 10-100) antibodySGOL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (AA 1-292) antibodySGOL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (Internal Region) antibodySGOL1 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (N-Term) antibodySGOL1 适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (AA 1-292) antibodySGOL1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (AA 395-444) antibodySGOL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (AA 260-439) antibodySGOL1 适用: 人, 小鼠 ELISA, WB, IF/ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- IF 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
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别名
- SGOL1
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背景
- The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.
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基因ID
- 151648
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UniProt
- Q5FBB7
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途径
- Maintenance of Protein Location
抗原
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