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MAP3K3 抗体

MAP3K3 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7258882
发货至: 中国
  • 抗原 See all MAP3K3 抗体
    MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))
    适用
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    人, 小鼠, 大鼠
    宿主
    • 43
    • 3
    克隆类型
    • 34
    • 12
    多克隆
    标记
    • 29
    • 3
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    • 2
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    • 1
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    This MAP3K3 antibody is un-conjugated
    应用范围
    • 37
    • 20
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    • 1
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    Immunohistochemistry (IHC)
    产品特性
    Polyclonal Antibody
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein of human MAP3K3 (NP_976226.1).
    亚型
    IgG
  • 应用备注
    IHC 1:100-1:200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))
    别名
    MAP3K3 (MAP3K3 产品)
    别名
    MAPKKK3 antibody, MEKK3 antibody, AW548911 antibody, Mekk3 antibody, mKIAA4031 antibody, mitogen activated protein kinase kinase kinase 3 antibody, mitogen-activated protein kinase kinase kinase 3 antibody, Map3k3 antibody, MAP3K3 antibody, map3k3 antibody
    背景
    This gene product is a 626-amino acid polypeptide that is 96.5 % identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively, it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
    基因ID
    4215
    UniProt
    Q99759
    途径
    MAPK Pathway
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