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ELANE 抗体

This anti-ELANE antibody (ABIN7256532) is a Rabbit Polyclonal antibody detecting ELANE in WB. Suitable for Human, Mouse.
产品编号 ABIN7256532
发货至: 中国

Quick Overview for ELANE 抗体 (ABIN7256532)

抗原

See all ELANE 抗体
ELANE (Elastase, Neutrophil Expressed (ELANE))

适用

  • 72
  • 6
  • 4
  • 2
  • 1
人, 小鼠

宿主

  • 53
  • 20
  • 5
  • 1

克隆类型

  • 48
  • 31
多克隆

标记

  • 49
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
This ELANE antibody is un-conjugated

应用范围

  • 38
  • 35
  • 23
  • 12
  • 11
  • 10
  • 10
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB)
  • 产品特性

    Polyclonal Antibody

    纯化方法

    Affinity purification

    免疫原

    Recombinant fusion protein of human ELANE (NP_001963.1).

    亚型

    IgG
  • 应用备注

    WB 1:500-1:2000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    ELANE (Elastase, Neutrophil Expressed (ELANE))

    别名

    ELANE

    背景

    Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.

    分子量

    Observed_MW: 29 kDa

    Calculated_MW: 28 kDa

    基因ID

    1991

    UniProt

    P08246
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