GCLC 抗体
Quick Overview for GCLC 抗体 (ABIN7252117)
抗原
See all GCLC 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Antigen affinity purification
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免疫原
- Fusion protein of human GCLC
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亚型
- IgG
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应用备注
- WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.8 mg/mL
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缓冲液
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
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别名
- GCLC
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背景
- Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
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分子量
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Observed_MW: Refer to figures
Calculated_MW: 73 kDa
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UniProt
- P48506
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途径
- Cell RedoxHomeostasis
抗原
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