beta Catenin 抗体 (pSer37)
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- 抗原 See all beta Catenin (CATNB) 抗体
- beta Catenin (CATNB) (Catenin, beta (CATNB))
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抗原表位
- pSer37
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This beta Catenin antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 产品特性
- Phosphorylated antibody
- 纯化方法
- Affinity purification
- 免疫原
- Synthesized peptide derived from human Catenin-beta around the phosphorylation site of Ser37
- 亚型
- IgG
- Top Product
- Discover our top product CATNB Primary Antibody
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- 应用备注
- WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- beta Catenin (CATNB) (Catenin, beta (CATNB))
- 别名
- Catenin beta (CATNB 产品)
- 背景
- Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
- 分子量
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Observed_MW: 85 kDa
Calculated_MW: 85 kDa
- UniProt
- P35222
- 途径
- Peptide Hormone Metabolism
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