ARNT 抗体
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北京 101111
Quick Overview for ARNT 抗体 (ABIN7250482)
抗原
See all ARNT 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Monoclonal Antibody
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纯化方法
- Protein A purification
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免疫原
- Recombinant Protein
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亚型
- IgG
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anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (AA 1-110) antibody
ARNT 适用: 人 WB, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3D10 unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (AA 1-789) antibodyARNT 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (N-Term) antibodyARNT 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (AA 416-789) antibodyARNT 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) antibodyARNT 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 2F11 unconjugated Recombinant Antibody
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) antibodyKD Validated ARNT 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB660 unconjugated Recombinant Antibody
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (C-Term) antibodyARNT 适用: 人, 小鼠, 大鼠, Cow, 兔, 绵羊, 豚鼠, 马, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) antibodyARNT 适用: 小鼠 WB, IHC, ELISA 宿主: 小鼠 Monoclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (N-Term) antibodyARNT 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (N-Term) antibodyARNT 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-2000, IHC 1:100-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT))
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别名
- HIF1 beta
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背景
- Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor that plays a critical role in the cellular response to hypoxia (1). The HIF1 complex consists of two subunits, HIF-1α and HIF-1β, which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family (2). HIF1 regulates the transcription of a broad range of genes that facilitate responses to the hypoxic environment, including genes regulating angiogenesis, erythropoiesis, cell cycle, metabolism and apoptosis. The widely expressed HIF-1α is typically degraded rapidly in normoxic cells by the ubiquitin/proteasomal pathway. Under normoxic conditions, HIF-1α is proline hydroxylated leading to a conformational change that promotes binding to the von Hippel Lindau protein (VLH) E3 ligase complex, ubiquitination and proteasomal degradation follows (3,4). Both hypoxic conditions and chemical hydroxylase inhibitors (such as desferrioxamine and cobalt) inhibit HIF-1α degradation and lead to its stabilization. In addition, HIF-1α can be induced in an oxygen-independent manner by various cytokines through the PI3K-AKT-mTOR pathway (5-7).HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex (8). Together with AhR, HIF-1β plays an important role in xenobiotics metabolism (8).
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分子量
- 87 kDa
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UniProt
- P27540
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途径
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect
抗原
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