MOB2 抗体
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北京 101111
Quick Overview for MOB2 抗体 (ABIN7248908)
抗原
See all MOB2 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Antigen affinity purification
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免疫原
- Synthetic peptide of human MOB2
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亚型
- IgG
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anti-MOB Kinase Activator 2 (MOB2) antibody
MOB2 适用: 人 DB, ICC 宿主: 小鼠 Monoclonal 2400C3a unconjugated
anti-MOB Kinase Activator 2 (MOB2) (AA 5-32), (N-Term) antibodyMOB2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24042 unconjugated
anti-MOB Kinase Activator 2 (MOB2) (AA 11-41), (N-Term) antibodyMOB2 适用: 人, 小鼠 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-MOB Kinase Activator 2 (MOB2) (AA 128-140) antibodyVerified MOB2 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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应用备注
- IHC 1:40-1:200, ELISA 1:5000-1:10000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.08 mg/mL
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缓冲液
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- MOB2 (MOB Kinase Activator 2 (MOB2))
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别名
- MOB2
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背景
- MOB2 (Mps one binder kinase activator-like 2), also known as HCCA2 (Hepatocellular carcinoma-associated gene 2), is a 467 amino acid protein that belongs to the MOB1/phocein family. MOB2 is expressed in lung, spleen, brain, and fetal liver. It is highly expressed in hepatocellular carcinoma. MOB2 is localized in the perinuclear region of the cytoplasm in liver cancer tissues and colocalizes with MAD2L2 in the nucleus of Hela cells. MOB2 is characterized by two N-glycosylation sites, six N-myristolylation sites, two Src homology 3 (SH3), and several phosphorylation motifs which indicate that this protein may play a role in an intracellular signal transduction cascade. MOB2 binds to and regulates the autophosphorylation of the related human serine/threonine kinase 38 (NDR1) and serine/threonine kinase 38L(NDR2). It has been shown that MOB2 plays a critical role in cell cycle regulation. Overexpression of the protein during the G0/G1 phase inhibits cell proliferation causing cell cycle arrest. Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.
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UniProt
- Q70IA6
抗原
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