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HIF1AN 抗体

HIF1AN 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7239416
发货至: 中国
  • 抗原 See all HIF1AN 抗体
    HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))
    适用
    • 84
    • 31
    • 22
    • 7
    • 7
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    • 5
    • 5
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    人, 小鼠
    宿主
    • 76
    • 7
    克隆类型
    • 68
    • 17
    多克隆
    标记
    • 47
    • 5
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    • 3
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    • 2
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    This HIF1AN antibody is un-conjugated
    应用范围
    • 48
    • 25
    • 14
    • 14
    • 14
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    • 12
    • 8
    • 4
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    • 2
    • 2
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    产品特性
    Polyclonal Antibody
    纯化方法
    Affinity purification
    免疫原
    Synthetic peptide of human HIF1AN
    亚型
    IgG
    Top Product
    Discover our top product HIF1AN Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:300
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.6 mg/mL
    缓冲液
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))
    别名
    HIF1AN (HIF1AN 产品)
    别名
    FIH1 antibody, 2310046M24Rik antibody, A830014H24Rik antibody, cb728 antibody, id:ibd5139 antibody, hypoxia inducible factor 1 alpha subunit inhibitor antibody, hypoxia-inducible factor 1, alpha subunit inhibitor antibody, hypoxia inducible factor 1, alpha subunit inhibitor antibody, hypoxia-inducible factor 1, alpha subunit inhibitor S homeolog antibody, HIF1AN antibody, Hif1an antibody, hif1an antibody, hif1an.S antibody
    背景
    Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1alpha. Specifically, FIH-1 operates as an asparaginyl hydroxylase. It catalyzes the hydroxylation of the beta-carbon of Asparagine residue 803 within the carboxy terminal transactivation domain of HIF-1alpha. This hydroxylation event blocks the association of HIF-1alpha with co-activators. FIH-1 also binds to von Hippel-Lindau (VHL) tumor suppressor protein, which represses transcriptional ac-tivity of HIF-1alpha. In transiently transfected human osteosarcoma cells, FIH-1 localizes to the cytoplasm.
    分子量
    40 kDa
    NCBI登录号
    NP_060372
    UniProt
    Q9NWT6
    途径
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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