SRPK1 antibody is human, mouse and rat reactive. Multiple isoforms of SRPK1 are known to exist, this antibody will detect all except isoforms b and e. SRPK1 antibody is predicted to not cross-react with SRPK2.
纯化方法
SRPK1 Antibody is affinity chromatography purified via peptide column.
免疫原
SRPK1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human SRPK1. The immunogen is located within the first 50 amino acids of SRPK1.
SRPK1 antibody can be used for the detection of SRPK1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry at 5 μ,g/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
SRPK1 Antibody is supplied in PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C,4 °C
储存方法
SRPK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
抗原
SRPK1
(SRSF Protein Kinase 1 (SRPK1))
别名
SRPK1
背景
SRPK1 and SRPK2, two Arginine/serine-rich (SR) protein-specific kinases constitute control circuits to regulate both constitutive and alternative pre-mRNA splicing and coordinate splicing with transcription in cells (1). They are highly specific for the phosphorylation of these RS proteins, and highly expressed in testis (1,2). SRPK1 plays a role in the condensation of sperm chromatin and controls the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis (3,4).