ARID1A 抗体 (N-Term)
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Quick Overview for ARID1A 抗体 (N-Term) (ABIN6992134)
抗原
See all ARID1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 580-630, N-Term
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特异性
- ARID1A antibody is human, mouse and rat reactive. Multiple isoforms of ARID1A protein are known to exist.
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纯化方法
- ARID1A antibody is affinity chromatography purified via peptide column.
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免疫原
- ARID1A antibody was raised against an 18 amino acid peptide near the amino terminus of human ARID1A. The immunogen is located within amino acids 580 - 630 of ARID1A.
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亚型
- IgG
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应用备注
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ARID1A antibody can be used for detection of ARID1A by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- ARID1A antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- ARID1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))
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别名
- ARID1A
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背景
- The ARID1A protein is a member of the SWI/SNF family, whose members are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. ARID1A is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin (1). It possesses a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. The C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that ARID1A confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions (2).
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分子量
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Predicted: 133, 227, 251 kDa
Observed: 130, 260 kDa -
基因ID
- 8289
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NCBI登录号
- NP_006006
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UniProt
- O14497
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Tube Formation
抗原
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