CRBN 抗体 (C-Term)
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北京 101111
Quick Overview for CRBN 抗体 (C-Term) (ABIN6992111)
抗原
See all CRBN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- CRBN antibody is human, mouse and rat reactive. At least two isoforms of CRBN are known to exist, this antibody will detect both isoforms.
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纯化方法
- CRBN antibody is affinity chromatography purified via peptide column.
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免疫原
- CRBN antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRBN. The immunogen is located within the last 50 amino acids of CRBN.
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亚型
- IgG
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anti-Cereblon (CRBN) (AA 1-280) antibody
CRBN 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cereblon (CRBN) (AA 1-442) antibodyCRBN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cereblon (CRBN) (AA 35-84) antibodyCRBN 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, Hamster, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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CRBN antibody can be used for detection of CRBN by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- CRBN antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- CRBN antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- CRBN (Cereblon (CRBN))
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别名
- CRBN
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背景
- CRBN, a member of the Lon protease protein family, plays a role in brain development (1). It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8 (2). CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain (3,4).
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分子量
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Predicted: 49 kDa
Observed: 54 kDa -
基因ID
- 51185
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NCBI登录号
- NP_057386
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UniProt
- Q96SW2
抗原
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