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LIMA1 抗体 (N-Term)

This anti-LIMA1 antibody (ABIN6992089) is a Rabbit Polyclonal antibody detecting LIMA1 in WB, ELISA, IF, IHC (p). Suitable for Human.
产品编号 ABIN6992089
发货至: 中国

Quick Overview for LIMA1 抗体 (N-Term) (ABIN6992089)

抗原

See all LIMA1 抗体
LIMA1 (LIM Domain and Actin Binding 1 (LIMA1))

适用

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宿主

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克隆类型

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多克隆

标记

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This LIMA1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    AA 230-280, N-Term

    特异性

    LIMA1 antibody is human specific. At least four isoforms of LIMA1 are known to exist, this antibody will only detect the three largest isoforms.

    纯化方法

    LIMA1 antibody is affinity chromatography purified via peptide column.

    免疫原

    LIMA1 antibody was raised against an 18 amino acid peptide near the amino terminus of human LIMA1. The immunogen is located within amino acids 230 - 280 of LIMA1.

    亚型

    IgG
  • 应用备注

    LIMA1 antibody can be used for detection of LIMA1 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    LIMA1 antibody is supplied in PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,4 °C

    储存方法

    LIMA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • 抗原

    LIMA1 (LIM Domain and Actin Binding 1 (LIMA1))

    别名

    LIMA1

    背景

    The Lim domain and actin-binding protein 1 (LIMA1) is cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles and is downregulated in some cancer cell lines (1,2). LIMA1 is also a key molecule linking the cadherin-catenin complex to the actin cytoskeleton (3). Recent studies have shown that EGF activates ERK1/2-dependent phosphorylation, ubiquitination and degradation of LIMA1, leading to increased invasiveness and metastasis of metastatic prostate cancer models (4).

    分子量

    Predicted: 50, 66, 84 kDa

    Observed: 65 kDa

    基因ID

    51474

    NCBI登录号

    NP_001107018

    UniProt

    Q9UHB6
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