DEPTOR 抗体 (AA 220-270)
Quick Overview for DEPTOR 抗体 (AA 220-270) (ABIN6992003)
抗原
See all DEPTOR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 220-270
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特异性
- DEPTOR antibody is human, mouse and rat reactive. At least three isoforms of DEPTOR are known to exist, this antibody will detect all three isoforms.
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纯化方法
- DEPTOR antibody is affinity chromatography purified via peptide column.
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免疫原
- DEPTOR antibody was raised against a 16 amino acid peptide near the center of human DEPTOR. The immunogen is located within amino acids 220 - 270 of DEPTOR.
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亚型
- IgG
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anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 56-170) antibody
DEPTOR 适用: 人, 小鼠, 大鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 1-409) antibodyDEPTOR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 1-220) antibodyDEPTOR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 86-120) antibodyDEPTOR 适用: 人 WB 宿主: 兔 Polyclonal RB57442 unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 3-38) antibodyDEPTOR 适用: 人 WB 宿主: 兔 Polyclonal RB57441 unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 1-409) antibodyDEPTOR 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 1-409) antibodyDEPTOR 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5B3 unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 230-280) antibodyDEPTOR 适用: 人, 大鼠, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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DEPTOR antibody can be used for detection of DEPTOR by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- DEPTOR Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- DEPTOR antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))
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别名
- DEPTO
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背景
- DEPTOR is an mTOR (mammalian target of rapamycin)-interacting protein whose expression is negatively regualted by mTOR complex 1 (mTORC1) and mTORC2 (1). Loss of DEPTOR activates RP6SK1, Akt1, and SGK1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities. DEPTOR expression is low in most cancers, but is often elevated in multiple myelomas (1). In respons to stimulation by mitogens, DEPTOR is rapidly phosphorylated leading to its ubiquitination and degradation, allowing mTOR to generate an auto-amplification loop to promotes its own full activation (2).
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分子量
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Predicted: 45 kDa
Observed: 42 kDa -
基因ID
- 64798
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NCBI登录号
- NP_073620
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UniProt
- Q8TB45
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途径
- PI3K-Akt Signaling, RTK signaling, Regulation of Cell Size, BCR Signaling, Warburg Effect
抗原
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