OLIG2 抗体 (N-Term)
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北京 101111
Quick Overview for OLIG2 抗体 (N-Term) (ABIN6991989)
抗原
See all OLIG2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 80-130, N-Term
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特异性
- OLIG2 antibody is human, mouse and rat reactive. It is predicted to not cross-react with other members of the OLIG family of proteins. At least three isoforms of OLIG2 are known to exist, this antibody will detect all three isoforms.
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纯化方法
- OLIG2 antibody is affinity chromatography purified via peptide column.
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免疫原
- OLIG2 antibody was raised against a 15 amino acid peptide near the amino terminus of human OLIG2. The immunogen is located within amino acids 80 - 130 of OLIG2.
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亚型
- IgG
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应用备注
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OLIG2 antibody can be used for detection of OLIG2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- OLIG2 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- OLIG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- OLIG2 (Oligodendrocyte Lineage Transcription Factor 2 (OLIG2))
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别名
- OLIG2
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背景
- The oligodendrocyte transcription factors 1 and 2 (OLIG1 and OLIG2, respectively) make up part of basic helix-loop-helix (bHLH) family of transcription factors that are specifically expressed in zones of the neuroepithelium from which oligodendrocyte precursors emerge (1). Both OLIG1 and OLIG2 genes are downstream targets of Sonic hedgehog and are expressed exclusively in the central nervous system (2). OLIG2 is first observed in the ventral most p3 progenitor domain of the ventral neural tube while OLIG1 is first expressed in the dorsal portion of the p3 domain (2). Mice overexpressing OLIG2 exhibit impaired potassium channel expression in neural progenitors and proliferation of these cells similar to that seen in Down Syndrome, suggesting that OLIG2 may play a role in this pathology (3).
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分子量
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Predicted: 36 kDa
Observed: 37 kDa -
基因ID
- 10215
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NCBI登录号
- NP_005797
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UniProt
- Q13516
抗原
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