FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist.
纯化方法
FMR1 antibody is affinity chromatography purified via peptide column.
免疫原
FMR1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FMR1. The immunogen is located within the last 50 amino acids of FMR1.
FMR1 antibody can be used for detection of FMR1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
FMR1 antibody is supplied in PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C,4 °C
储存方法
FMR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
抗原
FMR1
(Fragile X Mental Retardation 1 (FMR1))
别名
FMR1
背景
Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1). FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2). A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1). Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3).