KREMEN2 抗体 (C-Term)
Quick Overview for KREMEN2 抗体 (C-Term) (ABIN6991832)
抗原
See all KREMEN2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 390-440, C-Term
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特异性
- Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.
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纯化方法
- KREMEN2 Antibody is affinity chromatography purified via peptide column.
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免疫原
- Anti-KREMEN2 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human KREMEN2. The immunogen is located within amino acids 390-440 of KREMEN2.
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亚型
- IgG
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anti-Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 121-220) antibody
KREMEN2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 1-420) antibodyKREMEN2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 200-360) antibodyKREMEN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1-2 μ,g/mL, ICC: 5 μ,g/mL.
Antibody validated: Western Blot in human, mouse and rat samples, Immunocytochemistry in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- KREMEN2 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- KREMEN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))
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别名
- KREMEN2
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背景
- KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
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分子量
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Predicted: 49kD
Observed: 49kD kDa -
基因ID
- 79412
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NCBI登录号
- NP_757384
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UniProt
- Q8NCW0
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途径
- WNT signaling
抗原
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