PHLPP2 抗体 (C-Term)
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北京 101111
Quick Overview for PHLPP2 抗体 (C-Term) (ABIN6991747)
抗原
See all PHLPP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- At least three isoforms are known to exist, this antibody will detect the two largest isoforms. PHLPP2 antibody is predicted to not cross react with PHLPP1.
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纯化方法
- PHLPP2 Antibody is affinity chromatography purified via peptide column.
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免疫原
- PHLPP2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human PHLPP2. The immunogen is located within the last 50 amino acids of PHLPP2.
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亚型
- IgG
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anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) (C-Term) antibody
PHLPP2 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) (AA 1295-1323), (C-Term) antibodyPHLPP2 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB15007 unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) (C-Term) antibodyVerified PHLPP2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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PHLPP2 antibody can be used for detection of PHLPP2 by Western blot at 1 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PHLPP2 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- PHLPP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
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别名
- PHLPP2
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背景
- PHLPP2 Antibody: PHLPP2 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. PHLPP2 associates with and is inhibited by adenylyl cyclase type 6 (AC6), thereby allowing Akt activation.
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分子量
- 156 kDa
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基因ID
- 23035
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NCBI登录号
- NP_055835
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UniProt
- Q6ZVD8
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途径
- PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway
抗原
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