VKORC1 抗体 (N-Term)
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北京 101111
Quick Overview for VKORC1 抗体 (N-Term) (ABIN6991675)
抗原
See all VKORC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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纯化方法
- VKORC1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- VKORC1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human VKORC1. The immunogen is located within the first 50 amino acids of VKORC1.
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亚型
- IgG
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应用备注
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VKORC1 antibody can be used for detection of VKORC1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- VKORC1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- VKORC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- VKORC1 (Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1))
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别名
- VKORC1
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背景
- VKORC1 Antibody: Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.
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基因ID
- 79001
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NCBI登录号
- NP_076869
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UniProt
- Q9BQB6
抗原
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