SIK1 抗体 (AA 340-390)
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Quick Overview for SIK1 抗体 (AA 340-390) (ABIN6991527)
抗原
See all SIK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 340-390
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特异性
- Two isoforms of SIK1 are known to exist, this antibody will detect both isoforms. SIK1 antibody is predicted to not cross-react with other SIK protein family members.
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纯化方法
- SIK1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- SIK1 antibody was raised against an 18 amino acid synthetic peptide near the center of human SIK1. The immunogen is located within amino acids 340 - 390 of SIK1.
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亚型
- IgG
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应用备注
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SIK1 antibody can be used for detection of SIK1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- SIK1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- SIK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- SIK1 (Salt-Inducible Kinase 1 (SIK1))
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别名
- SIK1
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背景
- SIK1 Antibody: Salt-inducible kinase 1 (SIK1), also known as SNF1LK or MSK, plays a role in histone modification and G2/M cell cycle regulation. It is a 783 amino acid protein that contains one UBA domain and belongs to the Ser/Thr protein kinase family (AMPK subfamily). Localized to both the nucleus and the cytoplasm, SIK1 is a class II HDAC kinase that uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be important for the early stages of skeletal muscle growth and myocardial cell differentiation.
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基因ID
- 150094
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NCBI登录号
- NP_775490
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UniProt
- P57059
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process
抗原
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