ALKBH2 抗体 (C-Term)
Quick Overview for ALKBH2 抗体 (C-Term) (ABIN6991387)
抗原
See all ALKBH2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 180-230, C-Term
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纯化方法
- ALKBH2 Antibody is affinity chromatography purified via peptide column.
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免疫原
- ALKBH2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ALKBH2. The immunogen is located within amino acids 180 - 230 of ALKBH2.
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亚型
- IgG
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anti-AlkB, Alkylation Repair Homolog 2 (ALKBH2) (AA 1-261) antibody
ALKBH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 2 (ALKBH2) (AA 1-261) antibodyALKBH2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 2 (ALKBH2) (AA 108-157) antibodyALKBH2 适用: 人, 小鼠, 大鼠, 豚鼠, 兔, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 2 (ALKBH2) (Middle Region) antibodyALKBH2 适用: 人, 小鼠, 大鼠, 豚鼠, 兔, Cow, 犬, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 2 (ALKBH2) (C-Term) antibodyALKBH2 适用: 人, 小鼠, 大鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ALKBH2 antibody can be used for detection of ALKBH2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- ALKBH2 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- ALKBH2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- ALKBH2 (AlkB, Alkylation Repair Homolog 2 (ALKBH2))
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别名
- ALKBH2
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背景
- ALKBH2 Antibody: The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA, ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.
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基因ID
- 121642
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NCBI登录号
- NP_001138847
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UniProt
- Q6NS38
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途径
- DNA Damage Repair
抗原
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