ATG13 抗体 (C-Term)
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北京 101111
Quick Overview for ATG13 抗体 (C-Term) (ABIN6991353)
抗原
See all ATG13 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 450-500, C-Term
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特异性
- Multiple isoforms of ATG13 are known to exist.
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纯化方法
- ATG13 Antibody is affinity chromatography purified via peptide column.
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免疫原
- ATG13 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ATG13. The immunogen is located within amino acids 450 - 500 of ATG13.
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亚型
- IgG
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anti-Autophagy Related 13 (ATG13) (AA 281-480) antibody
ATG13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Autophagy Related 13 (ATG13) (AA 339-550) antibodyATG13 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 6B2E12 unconjugated
anti-Autophagy Related 13 (ATG13) (AA 339-550) antibodyATG13 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 3E4C8 unconjugated
anti-Autophagy Related 13 (ATG13) (AA 51-150) antibodyATG13 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Autophagy Related 13 (ATG13) (AA 315-517) antibodyATG13 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Autophagy Related 13 (ATG13) (AA 318-517) antibodyATG13 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Autophagy Related 13 (ATG13) antibodyKD Validated ATG13 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3830 unconjugated Recombinant Antibody
anti-Autophagy Related 13 (ATG13) (AA 1-30) antibodyATG13 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Autophagy Related 13 (ATG13) (pSer318) antibodyATG13 适用: 人 WB, ELISA, DB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Autophagy Related 13 (ATG13) (AA 333-362) antibodyATG13 适用: 人 WB 宿主: 兔 Polyclonal RB40773 unconjugated
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应用备注
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ATG13 antibody can be used for detection of ATG13 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in rat samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- ATG13 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- ATG13 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- ATG13 (Autophagy Related 13 (ATG13))
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别名
- ATG13
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背景
- ATG13 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions, inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.
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分子量
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Predicted: 44, 53, 57, 61 kDa
Observed: 49 kDa -
基因ID
- 9776
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NCBI登录号
- NP_001136145
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UniProt
- O75143
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途径
- PI3K-Akt Signaling, Autophagy
抗原
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