KDM4A 抗体 (AA 340-390)
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北京 101111
Quick Overview for KDM4A 抗体 (AA 340-390) (ABIN6991179)
抗原
See all KDM4A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 340-390
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纯化方法
- JMJD2A Antibody is affinity chromatography purified via peptide column.
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免疫原
- JMJD2A antibody was raised against a 14 amino acid synthetic peptide from near the center of human JMJD2A. The immunogen is located within amino acids 340 - 390 of JMJD2A.
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亚型
- IgG
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应用备注
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JMJD2A antibody can be used for detection of JMJD2A by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- JMJD2A Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- JMJD2A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- KDM4A (Lysine (K)-Specific Demethylase 4A (KDM4A))
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别名
- JMJD2A
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背景
- JMJD2A Antibody: Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. The first member of this group, JMJD2A, is widely expressed in human tissues and cell lines and functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. JMJD2A can also form a complex with the androgen receptor (AR), a transcription factor that is pivotal for the development of prostate cancer. Overexpression of JMJD2A stimulates AR function and this stimulation is dependent on JMJD2A catalytic activity, suggesting that JMJD2A might be a critical protein with roles in cell proliferation and oncogenesis.
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基因ID
- 9682
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UniProt
- O75164
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途径
- Warburg Effect
抗原
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