PALB2 抗体 (C-Term)
Quick Overview for PALB2 抗体 (C-Term) (ABIN6991161)
抗原
See all PALB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 940-990, C-Term
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特异性
- At least four isoforms of PALB2 are known to exist, this antibody will detect all four isoforms.
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纯化方法
- PALB2 Antibody is affinity chromatography purified via peptide column.
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免疫原
- PALB2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human PALB2. The immunogen is located within amino acids 940 - 990 of PALB2.
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亚型
- IgG
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anti-Partner and Localizer of BRCA2 (PALB2) (AA 1101-1186) antibody
PALB2 适用: 人, Pig WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Partner and Localizer of BRCA2 (PALB2) (AA 675-725) antibodyPALB2 适用: 人 WB, IHC, IP, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Partner and Localizer of BRCA2 (PALB2) (AA 677-726) antibodyPALB2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Partner and Localizer of BRCA2 (PALB2) (AA 99-198) antibodyPALB2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Partner and Localizer of BRCA2 (PALB2) (AA 546-574) antibodyPALB2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB19074 unconjugated
anti-Partner and Localizer of BRCA2 (PALB2) (C-Term) antibodyPALB2 适用: 人, 小鼠, 大鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
anti-Partner and Localizer of BRCA2 (PALB2) (AA 553-582), (Middle Region) antibodyPALB2 适用: 人 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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PALB2 antibody can be used for detection of PALB2 by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PALB2 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- PALB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- PALB2 (Partner and Localizer of BRCA2 (PALB2))
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别名
- PALB2
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背景
- PALB2 Antibody: The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments.
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分子量
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Predicted: 65, 100, 130 kDa
Observed: 140 kDa -
基因ID
- 79728
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UniProt
- Q86YC2
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途径
- DNA Damage Repair
抗原
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