Norrie Disease (Pseudoglioma) 抗体 (N-Term)
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- 抗原 See all Norrie Disease (Pseudoglioma) (NDP) 抗体
- Norrie Disease (Pseudoglioma) (NDP)
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Norrie Disease (Pseudoglioma) antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
- 纯化方法
- Norrin Antibody is affinity chromatography purified via peptide column.
- 免疫原
- Norrin antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human Norrin. The immunogen is located within the first 50 amino acids of Norrin.
- 亚型
- IgG
- Top Product
- Discover our top product NDP Primary Antibody
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anti-Norrie Disease (Pseudoglioma) (NDP) antibody
NDP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Norrie Disease (Pseudoglioma) (NDP) (AA 25-133) antibodyNDP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Norrie Disease (Pseudoglioma) (NDP) (AA 25-133) antibodyNDP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Norrie Disease (Pseudoglioma) (NDP) antibodyNDP 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Norrie Disease (Pseudoglioma) (NDP) (AA 1-133) antibodyNDP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Norrie Disease (Pseudoglioma) (NDP) (Middle Region) antibodyNDP 适用: 人, 小鼠, 大鼠, 马, 兔, Cow, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Norrie Disease (Pseudoglioma) (NDP) (N-Term) antibodyNDP 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Norrin antibody can be used for detection of Norrin by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Norrin Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- Norrin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- Norrie Disease (Pseudoglioma) (NDP)
- 别名
- Norrin (NDP 产品)
- 别名
- EVR2 antibody, FEVR antibody, ND antibody, evr2 antibody, fevr antibody, xnorrin antibody, Ndph antibody, RGD1563968 antibody, NDP, norrin cystine knot growth factor antibody, Norrie disease (pseudoglioma) L homeolog antibody, Norrie disease (pseudoglioma) (human) antibody, NDP antibody, ndp.L antibody, Ndp antibody
- 背景
- Norrin Antibody: Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/beta-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina, transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/beta-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.
- 基因ID
- 4693
- NCBI登录号
- NP_000257
- UniProt
- Q00604
- 途径
- Sensory Perception of Sound
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