GP6 抗体 (C-Term, Isoform 2)
Quick Overview for GP6 抗体 (C-Term, Isoform 2) (ABIN6990965)
抗原
See all GP6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term, Isoform 2
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特异性
- At least three GPVI isoforms are known to exist, this antibody will detect the two longest isoforms. Because of its extensive glycosylation, GPVI often migrates at a higher than expected molecular weight in SDS-PAGE.
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纯化方法
- GPVI Antibody is affinity chromatography purified via peptide column.
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免疫原
- GPVI antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of isoform 2 of the human GPVI. The immunogen is located within the last 50 amino acids of GPVI.
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亚型
- IgG
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anti-Glycoprotein VI (Platelet) (GP6) (AA 86-231) antibody
GP6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein VI (Platelet) (GP6) (AA 115-265) antibodyGP6 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein VI (Platelet) (GP6) (AA 309-337), (C-Term) antibodyGP6 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22884 unconjugated
anti-Glycoprotein VI (Platelet) (GP6) antibodyGP6 适用: 人 FACS 宿主: 兔 Chimeric unconjugated Fc fragment
anti-Glycoprotein VI (Platelet) (GP6) (C-Term) antibodyGP6 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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GPVI antibody can be used for detection of GPVI by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- GPVI Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- GPVI antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- GP6 (Glycoprotein VI (Platelet) (GP6))
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别名
- GPVI
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背景
- GPVI Antibody: Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.
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分子量
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Predicted: 68 kDa
Observed: 67 kDa -
基因ID
- 51206
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NCBI登录号
- NP_057447
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UniProt
- Q9HCN6
抗原
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