AMBRA1 抗体 (N-Term)
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北京 101111
Quick Overview for AMBRA1 抗体 (N-Term) (ABIN6990889)
抗原
See all AMBRA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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纯化方法
- Ambra1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- Ambra1 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human Ambra1. The immunogen is located within the first 50 amino acids of Ambra1.
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亚型
- IgG
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anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (AA 1109-1208) antibody
AMBRA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibodyAMBRA1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (AA 221-320) antibodyAMBRA1 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (AA 1177-1301) antibodyAMBRA1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6B11D1 unconjugated
anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (AA 961-1208) antibodyAMBRA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (AA 1-50) antibodyAMBRA1 适用: 人, 小鼠, 大鼠, 小鸡, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (AA 27-55), (N-Term) antibodyAMBRA1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB13139 unconjugated
anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (C-Term) antibodyAMBRA1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibodyAMBRA1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Ambra1 antibody can be used for the detection of Ambra1 by Western blot at 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Ambra1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- Ambra1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- AMBRA1 (Autophagy/beclin-1 Regulator 1 (AMBRA1))
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别名
- Ambra1
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背景
- Ambra1 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death. Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.
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基因ID
- 55626
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UniProt
- Q9C0C7
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途径
- Autophagy
抗原
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