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MANF 抗体 (C-Term)

This anti-MANF antibody (ABIN6990751) is a Rabbit Polyclonal antibody detecting MANF in WB, ELISA, IF, IHC (p). Suitable for Human, Mouse, Rat.
产品编号 ABIN6990751
发货至: 中国

Quick Overview for MANF 抗体 (C-Term) (ABIN6990751)

抗原

See all MANF 抗体
MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This MANF antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

KO Validated
  • 抗原表位

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    C-Term

    特异性

    This antibody does not cross-react with CDNF. The specificity of this antibody was further verified by MANF specific knockout. MANF signal was not detected in MANF knockout HEK293T cells as compared to that in control wild type cells.

    纯化方法

    MANF Antibody is affinity chromatography purified via peptide column.

    免疫原

    MANF antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus of human MANF. The immunogen is located within the last 50 amino acids of MANF.

    亚型

    IgG
  • 应用备注

    WB: 0.125-2 μ,g/mL, IHC: 2.5 μ,g/mL, IF: 20 μ,g/mL

    Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    MANF Antibody is supplied in PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,4 °C

    储存方法

    MANF antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原

    MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

    别名

    MANF

    背景

    MANF Antibody: MANF, also known as ARMET, was initially identified as a protein containing an arginine-rich region that was highly mutated in a variety of tumors. More recently it was identified as a mesencephalic astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons, similar to glial cell line-derived neurotrophic factor (GDNF) and CDNF. In rat brain slices, MANF enhanced nigral gamma-aminobutyric acid release. Like GDNF and CDNF, MANF has selective neuroprotective activity for dopaminergic neurons suggesting that it may be indicated for the treatment of Parkinson's disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.

    分子量

    Predicted: 20kD

    Observed: 18 kD kDa

    基因ID

    7873

    UniProt

    P55145
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