HAP1 抗体 (AA 310-360)
Quick Overview for HAP1 抗体 (AA 310-360) (ABIN6990748)
抗原
See all HAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 310-360
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纯化方法
- HAP1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- HAP1 antibody was raised against a 19 amino acid synthetic peptide from near the center of human HAP1. The immunogen is located within amino acids 310 - 360 of HAP1.
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亚型
- IgG
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anti-Huntingtin Associated Protein 1 (HAP1) (Internal Region) antibody
Verified HAP1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 132-328) antibodyHAP1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 328-580) antibodyHAP1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (C-Term) antibodyVerified HAP1 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 1-671) antibodyHAP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 1-671) antibodyHAP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 160-381) antibodyHAP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 349-584) antibodyHAP1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) antibodyHAP1 适用: 大鼠 WB, IHC, IP 宿主: 小鼠 Monoclonal 1B6 unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (Center) antibodyHAP1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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HAP1 antibody can be used for detection of HAP1 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- HAP1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- HAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- HAP1 (Huntingtin Associated Protein 1 (HAP1))
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别名
- HAP1
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背景
- HAP1 Antibody: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening, the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
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基因ID
- 9001
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UniProt
- P54257
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途径
- Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
抗原
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