TIGAR 抗体 (AA 100-150)
Quick Overview for TIGAR 抗体 (AA 100-150) (ABIN6990720)
抗原
See all TIGAR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 100-150
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纯化方法
- TIGAR Antibody is affinity chromatography purified via peptide column.
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免疫原
- TIGAR antibody was raised against a 19 amino acid synthetic peptide from near the center of human TIGAR. The immunogen is located within amino acids 100 - 150 of TIGAR.
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亚型
- IgG
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anti-TP53 induced glycolysis regulatory phosphatase (TIGAR) (AA 24-188) antibody
TIGAR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TP53 induced glycolysis regulatory phosphatase (TIGAR) (AA 161-270) antibodyTIGAR 适用: 小鼠 ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TP53 induced glycolysis regulatory phosphatase (TIGAR) (AA 220-270) antibodyTIGAR 适用: 人 IHC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-TP53 induced glycolysis regulatory phosphatase (TIGAR) (AA 1-270) antibodyTIGAR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-TP53 induced glycolysis regulatory phosphatase (TIGAR) (Center) antibodyTIGAR 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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TIGAR antibody can be used for detection of TIGAR by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- TIGAR Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- TIGAR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))
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别名
- TIGAR
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背景
- TIGAR Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death, loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.
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基因ID
- 57103
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NCBI登录号
- NP_065108
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UniProt
- Q9NQ88
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途径
- Warburg Effect
抗原
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