BIM 抗体 (AA 80-130)
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北京 101111
Quick Overview for BIM 抗体 (AA 80-130) (ABIN6990661)
抗原
See all BIM (BCL2L11) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 80-130
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纯化方法
- Bim Antibody is affinity chromatography purified via peptide column.
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免疫原
- Anti-BIM antibody was raised against a peptide corresponding to amino acids near the center of human BIM. The immunogen is located within amino acids 80-130 of BIM.
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亚型
- IgG
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应用备注
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WB: 5 μ,g/mL, ICC: 10 μ,g/mL, IF: 20 μ,g/mL.
Antibody validated: Western Blot in human and mouse samples, Immunocytochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Bim Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- Bim antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
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别名
- Bim
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背景
- Bim Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
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分子量
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Predicted: 22kD
Observed: 22kD kDa -
基因ID
- 10018
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UniProt
- O43521
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途径
- PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity
抗原
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