TLR6 抗体 (N-Term)
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Quick Overview for TLR6 抗体 (N-Term) (ABIN6990589)
抗原
See all TLR6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 160-210, N-Term
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特异性
- This TLR6 antibody is predicted to have no cross-reactivity to other members of the TLR protein family.
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纯化方法
- TLR6 Antibody is affinity chromatography purified via peptide column.
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免疫原
- TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR6. The immunogen is located within amino acids 160 - 210 of TLR6.
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亚型
- IgG
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应用备注
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TLR6 antibody can be used for detection of TLR6 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- TLR6 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- TLR6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- TLR6 (Toll-Like Receptor 6 (TLR6))
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别名
- TLR6
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背景
- TLR6 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69 % sequence identify. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses.
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分子量
- Observed: 91 kDa
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基因ID
- 10333
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NCBI登录号
- NP_006059
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UniProt
- Q9Y2C9
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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