TLR5 抗体 (AA 450-500)
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北京 101111
Quick Overview for TLR5 抗体 (AA 450-500) (ABIN6990587)
抗原
See all TLR5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 450-500
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纯化方法
- TLR5 Antibody is affinity chromatography purified via peptide column.
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免疫原
- TLR5 antibody was raised against a peptide corresponding to 16 amino acids near the center of human TLR5. The immunogen is located within amino acids 450 - 500 of TLR5.
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亚型
- IgG
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应用备注
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TLR5 antibody can be used for detection of TLR5 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- TLR5 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- TLR5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- TLR5 (Toll-Like Receptor 5 (TLR5))
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别名
- TLR5
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背景
- TLR5 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-κ,B, leading to the activation of TNF-α, and other cytokines. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires'disease and demonstrates the importance of TLR5 in the innate immune response.
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分子量
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Predicted: 94 kDa
Observed: 94 kDa -
基因ID
- 7100
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NCBI登录号
- NP_003259
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UniProt
- O60602
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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