BACE1 抗体 (C-Term)
Quick Overview for BACE1 抗体 (C-Term) (ABIN6990574)
抗原
See all BACE1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- BACE Antibody is Ion exchange chromatography purified.
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免疫原
- Anti-BACE antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human BACE. The immunogen is located within the last 50 amino acids of BACE.
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亚型
- IgG
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anti-Beta-secretase 1 (BACE1) (AA 22-501) antibody
BACE1 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 2C1 unconjugated
anti-Beta-secretase 1 (BACE1) (AA 112-324) antibodyBACE1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3C1C3 unconjugated
anti-Beta-secretase 1 (BACE1) (N-Term) antibodyBACE1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (AA 401-501) antibodyBACE1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (AA 22-322) antibodyBACE1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (AA 46-155) antibodyBACE1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (AA 72-121) antibodyBACE1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 猴, Pig, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (C-Term) antibodyBACE1 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (N-Term) antibodyBACE1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (AA 38-70), (N-Term) antibodyBACE1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB16874 unconjugated
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应用备注
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WB: 1 μ,g/mL, IHC-P: 2.5 μ,g/mL, ICC: 10 μ,g/mL, IF: 20 μ,g/mL.
Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry, Immunocytochemistry and Immunofluorescence in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- BACE Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- BACE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- BACE1 (Beta-secretase 1 (BACE1))
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别名
- BACE
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背景
- BACE Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
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分子量
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Predicted: 55kD
Observed: 65kD (Post-modification: 4 N-linked glycosylation) kDa -
基因ID
- 23621
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UniProt
- P56817
抗原
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