AES 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for AES 抗体 (C-Term) (ABIN6990571)
抗原
See all AES 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
纯化方法
- AES Antibody is affinity chromatography purified via peptide column.
-
免疫原
- AES antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human AES. The immunogen is located within the last 50 amino acids of AES.
-
亚型
- IgG
-
-
anti-Amino-terminal Enhancer of Split (AES) (N-Term) antibody
AES 适用: 人, 小鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (AA 1-264) antibodyAES 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (N-Term) antibodyVerified AES 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (C-Term) antibodyAES 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (C-Term), (N-Term) antibodyAES 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (AA 1-264) antibodyAES 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (AA 1-264) antibodyAES 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (AA 1-264) antibodyAES 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (C-Term) antibodyAES 适用: 人, 小鼠, 大鼠, Cow, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (N-Term) antibodyAES 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 非洲爪蟾, 猴 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
AES antibody can be used for the detection of AES by Western blot at 1 - 4 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- AES Antibody is supplied in PBS containing 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,4 °C
-
储存方法
- AES antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
-
- AES (Amino-terminal Enhancer of Split (AES))
-
别名
- AES
-
背景
- AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.
-
基因ID
- 166
-
NCBI登录号
- NP_945320
-
UniProt
- Q08117
-
途径
- WNT signaling, SARS-CoV-2 Protein Interactome
抗原
-
