IRAK2 抗体 (C-Term)
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Quick Overview for IRAK2 抗体 (C-Term) (ABIN6990565)
抗原
See all IRAK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- At least four isoforms of IRAK2 are known to exist, this antibody will detect all four isoforms. Anti-IRAK2 has no cross response to IRAK.
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纯化方法
- IRAK2 Antibody is affinity chromatography purified via peptide column.
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免疫原
- IRAK2 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of mouse IRAK2a. The immunogen is located within the last 50 amino acids of IRAK2.
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亚型
- IgG
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anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) antibody
IRAK2 适用: 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (AA 111-210) antibodyIRAK2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6C7 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (C-Term) antibodyIRAK2 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (AA 211-458) antibodyIRAK2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) antibodyIRAK2 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB6365 unconjugated Recombinant Antibody
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (AA 1-270) antibodyIRAK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (AA 1-270) antibodyIRAK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) antibodyIRAK2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) antibodyKD Validated IRAK2 适用: 人 WB 宿主: 小鼠 Monoclonal 25GB3735 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) antibodyIRAK2 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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IRAK2 antibody can be used for detection of IRAK2 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 1 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunocytochemistry in mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- IRAK2 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- IRAK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- IRAK2 (Interleukin-1 Receptor-Associated Kinase 2 (IRAK2))
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别名
- IRAK2
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背景
- IRAK2 Antibody: The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-κ,B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family has been identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-κ,B activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kB activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. Unlike human IRAK2, murine IRAK2 exists as four alternately spliced isoforms (IRAK2a-d), with two isoforms (IRAK2c and d) acting in an inhibitory fashion. IRAK2 is expressed in a variety of tissues.
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分子量
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Predicted: 68 kDa
Observed: 65 kDa -
基因ID
- 108960
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UniProt
- Q8CFA1
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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