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RHEB 抗体 (Middle Region)

RHEB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6990534
发货至: 中国
  • 抗原 See all RHEB 抗体
    RHEB (Ras Homolog Enriched in Brain (RHEB))
    抗原表位
    • 15
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 40-90, Middle Region
    适用
    • 46
    • 44
    • 35
    • 8
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 57
    • 4
    克隆类型
    • 47
    • 13
    多克隆
    标记
    • 25
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RHEB antibody is un-conjugated
    应用范围
    • 42
    • 16
    • 14
    • 14
    • 9
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    纯化方法
    Rheb Antibody is affinity chromatography purified via peptide column.
    免疫原
    Rheb antibody was raised against a 15 amino acid synthetic peptide from the middle region of human Rheb. The immunogen is located within amino acids 40 - 90 of Rheb.
    亚型
    IgG
    Top Product
    Discover our top product RHEB Primary Antibody
  • 应用备注
    Rheb antibody can be used for the detection of Rheb by Western blot at 1 to 4 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rheb Antibody is supplied in PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,4 °C
    储存方法
    Rheb antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原
    RHEB (Ras Homolog Enriched in Brain (RHEB))
    别名
    Rheb (RHEB 产品)
    别名
    RHEB2 antibody, RHEB antibody, rheb2 antibody, CG1081 antibody, DReb antibody, Dm Rheb antibody, DmRheb antibody, Dmel\CG1081 antibody, Q9VND8 antibody, RheB antibody, dRheb antibody, rheb antibody, Ras homolog, mTORC1 binding antibody, Ras homolog enriched in brain antibody, ras homolog enriched in brain antibody, Ras homolog, mTORC1 binding L homeolog antibody, RHEB antibody, Rheb antibody, rheb antibody, rheb.L antibody
    背景
    Rheb Antibody: Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.
    分子量
    19, 20 kDa
    基因ID
    6009
    UniProt
    Q15382
    途径
    RTK signaling
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