Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) 抗体
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- 抗原 See all Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) 抗体
- Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- NADE Antibody is Ion exchange chromatography purified.
- 免疫原
- NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE. The immunogen is located within the last 50 amino acids of NADE.
- 亚型
- IgG
- Top Product
- Discover our top product NGFRAP1 Primary Antibody
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anti-Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (Center) antibody
NGFRAP1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (AA 1-111) antibodyNGFRAP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (AA 1-101) antibodyNGFRAP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (AA 1-110) antibodyNGFRAP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E5 unconjugated
anti-Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (AA 1-111) antibodyNGFRAP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (Middle Region) antibodyNGFRAP1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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NADE antibody can be used for detection of NADE by Western blot at 1 μ,g/mL. Despite its predicted molecular weight, NADE migrates at ~23 kDa in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- NADE Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- NADE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)
- 别名
- NADE (NGFRAP1 产品)
- 背景
- NADE Antibody: The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.
- 基因ID
- 27018
- NCBI登录号
- NP_996798
- UniProt
- Q00994
- 途径
- Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity
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