PD-L1 抗体 (Isoform 1)
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北京 101111
Quick Overview for PD-L1 抗体 (Isoform 1) (ABIN6990335)
抗原
See all PD-L1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 60-110, Isoform 1
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特异性
- PD-L1 antibody has no cross-reactivity to PD-L2.
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纯化方法
- PD-L1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- Anti-PD-L1 antibody was raised against a peptide corresponding to 17 amino acids near the center of human PD-L1 isoform 1. The immunogen is located within amino acids 60 - 110 of PD-L1.
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亚型
- IgG
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anti-CD274 (PD-L1) (C-Term) antibody
Verified PD-L1 适用: 人 WB, FACS, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-CD274 (PD-L1) (AA 19-238) antibodyPD-L1 适用: 人 WB, FACS, IHC, ELISA, IF 宿主: 小鼠 Monoclonal 9B5F4 unconjugated
anti-CD274 (PD-L1) (AA 39-191) antibodyPD-L1 适用: 人, 小鼠 WB, FACS, IHC, ELISA, IF, Coat, StM 宿主: 小鼠 Monoclonal PDL1-2746 unconjugated
anti-CD274 (PD-L1) (AA 24-153) antibodyPD-L1 适用: 人 FACS, IHC, ELISA 宿主: 小鼠 Monoclonal 6D9A2 unconjugated
anti-CD274 (PD-L1) (AA 48-290) antibodyPD-L1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-CD274 (PD-L1) (AA 34-241) antibodyPD-L1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-CD274 (PD-L1) (C-Term) antibodyKO Validated PD-L1 适用: 人 WB, FACS, ICC, IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-CD274 (PD-L1) (AA 24-153) antibodyPD-L1 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 7D2A10 unconjugated
anti-CD274 (PD-L1) (AA 24-234) antibodyPD-L1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD274 (PD-L1) antibodyPD-L1 适用: 人 IHC 宿主: 兔 Monoclonal 711R unconjugated Recombinant Antibody
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应用备注
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WB: 1-2 μ,g/mL, IHC-P: 2.5-5 μ,g/mL, IF: 20 μ,g/mL, Flow Cyt: 0.5 μ,g/mL.
Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in human and rat samples, Immunofluorescence in human and rat samples and Flow Cytometry in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PD-L1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- PD-L1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- PD-L1 (CD274 (PD-L1))
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别名
- PD-L1
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背景
- PD-L1 plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, PD-L1 modulates the activation threshold of T-cells and limits T-cell effector response (1). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (2,3). Through a yet unknown activating receptor, it may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (4).
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分子量
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Predicted: 33 kDa
Observed: 37 kDa -
基因ID
- 29126
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NCBI登录号
- NP_054862
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UniProt
- Q9NZQ7
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途径
- Cancer Immune Checkpoints
抗原
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