NIK Antibody is affinity chromatography purified via peptide column.
免疫原
NIK antibody was raised against a 17 amino acid peptide near the carboxy terminus of human NIK. The immunogen is located within the last 50 amino acids of NIK.
NIK antibody can be used for detection of NIK by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
NIK Antibody is supplied in PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C,4 °C
储存方法
NIK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
抗原
MAP3K14
(Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))
别名
NIK
背景
NIK Antibody: Nuclear factor kappa B (NF-κ,B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ,B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα, LPS and mitogens. A serine/threonine protein kinase which mediates NF-κ,B activation by IL-1, TNFα, and CD95 was identified recently and designated NIK (for NF-κ,B inducing kinase). NIK is an activator of Iκ,B kinase alpha and beta (IKKα, and IKKβ,). Therefore, NIK is a key molecule in the NF-κ,B signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.