MSH6 抗体
Quick Overview for MSH6 抗体 (ABIN6989836)
抗原
See all MSH6 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 猴, 小鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human MSH6 (NP_000170.1).
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亚型
- IgG
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应用备注
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WB 1:300-5000
IHC()
IF() -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
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别名
- MSH6
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背景
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Synonyms: MSH6,GTBP,GTMBP,HNPCC5,HSAP,p160
Background: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
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基因ID
- 2956
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UniProt
- P52701
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途径
- DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response
抗原
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