EGLN1 抗体
Quick Overview for EGLN1 抗体 (ABIN6989779)
抗原
See all EGLN1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-426 of human EGLN1 (NP_071334.1).
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亚型
- IgG
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()
IF() -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
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别名
- EGLN1
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背景
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Synonyms: EGLN1,C1orf12,ECYT3,HALAH,HIF-PH2,HIFPH2,HPH-2,HPH2,PHD2,SM20,ZMYND6
Background: The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
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基因ID
- 54583
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UniProt
- Q9GZT9
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途径
- cAMP Metabolic Process, Warburg Effect
抗原
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