RRAGA + RRAGB (AA 231-313) 抗体
Our Local Distributor
北京 101111
Quick Overview for RRAGA + RRAGB (AA 231-313) 抗体 (ABIN6989150)
抗原
适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 231-313
-
交叉反应
- 小鼠, 大鼠
-
预测反应
- Human,Dog,Sheep,Pig,Horse
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human RRAGA and RRAGB
-
亚型
- IgG
-
-
-
-
应用备注
-
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
-
有效期
- 12 months
-
-
- RRAGA + RRAGB
-
背景
-
Synonyms: FIP1, RAGA, FIP-1, RRAGB, Adenovirus E3 14.7 kDa-interacting protein 1, Rag A, RAg B, RagA, RAGB, Ras related GTP binding protein A, RRAGA_HUMAN, Ras-related GTP binding A? GTP-binding protein ragB, Rag B, RagB, Ras-related GTP-binding protein B, RRAGB, RRAGB_HUMAN..
Background: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
-
基因ID
- 10670
-
UniProt
- Q7L523
抗原
-
