Cyclin D2 抗体 (AA 161-288) (PE)
Quick Overview for Cyclin D2 抗体 (AA 161-288) (PE) (ABIN6988260)
抗原
See all Cyclin D2 (CCND2) 抗体适用
宿主
克隆类型
标记
应用范围
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    - 
                                            抗原表位
- AA 161-288
- 
                                            交叉反应
- 人, 小鼠, 大鼠
- 
                                            纯化方法
- Purified by Protein A.
- 
                                            免疫原
- KLH conjugated synthetic peptide derived from human Cyclin D2
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                                            亚型
- IgG
 
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    - 
                                            应用备注
- FCM 1:20-100
- 
                                            限制
- 仅限研究用
 
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    - 
                                            状态
- Liquid
- 
                                            浓度
- 1 μg/μL
- 
                                            缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 
                                            储存液
- ProClin
- 
                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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                                            储存条件
- -20 °C
- 
                                            储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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                                            有效期
- 12 months
 
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    - Cyclin D2 (CCND2)
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                                            别名
- Cyclin D2
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                                            背景
- 
                        Synonyms: MPPH3, KIAK2, G1/S-specific cyclin-D2, CCND2 Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). 
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                                            基因ID
- 894
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                                            UniProt
- P30279
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                                            途径
- Cell Division Cycle, Mitotic G1-G1/S Phases
 抗原
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