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PTEN 抗体 (pSer380, pThr382, pThr383) (Cy5.5)

Name: PTEN 抗体 (pSer380, pThr382, pThr383) (Cy5.5)
SKU: ABIN6985648
Availability: OutOfStock

This anti-PTEN antibody is a 兔多克隆 antibody detecting PTEN in WB, FACS, IF (cc) 和 IF (p). Suitable for 人, 小鼠和大鼠.

产品编号 ABIN6985648

发货至: 中国

Quick Overview for PTEN 抗体 (pSer380, pThr382, pThr383) (Cy5.5) (ABIN6985648)

抗原

See all PTEN 抗体

PTEN (Phosphatase and Tensin Homolog (PTEN))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This PTEN antibody is conjugated to Cy5.5

应用范围

Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Discover our top product PTEN Primary Antibody

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pSer380, pThr382, pThr383

交叉反应

人, 小鼠, 大鼠

预测反应

Dog,Cow,Pig,Horse,Chicken

纯化方法

Purified by Protein A.

免疫原

KLH conjugated Synthesised phosphopeptide derived from human PTEN around the phosphorylation site of Ser380/Thr382/Thr383

亚型

IgG
anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104), (N-Term) antibody
PTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB05082 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104) antibody
PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295), (C-Term) antibody
PTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB5083 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 306-335) antibody
PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295) antibody
PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 363-392) antibody
PTEN 适用: 人 WB 宿主: 兔 Polyclonal RB39439 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 371-403) antibody
PTEN 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 10-44), (N-Term) antibody
PTEN 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal 1096CT4-3-3 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (pSer385) antibody
PTEN 适用: 人 DB 宿主: 兔 Polyclonal RB39440 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (pTyr315) antibody
PTEN 适用: 人 DB 宿主: 兔 Polyclonal RB30516 unconjugated

应用备注

FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

有效期

12 months
抗原

PTEN (Phosphatase and Tensin Homolog (PTEN))

别名

PTEN

背景

Synonyms: PTEN(Phospho-Ser380/Thr382/Thr383), PTEN(phospho S380/T382/Thr383), PTEN(Phospho-Ser380/Thr382/Thr383), ITGA 2, MGC11227, MHAM, MMAC 1, MMAC1, Bannayan Zonana, BZS a, Multiple hamartoma (Cowden syndrome), Mutated in Mutiple Advanced Cancers 1, Phosphatase and Tensin Homolog, Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN, Phosphatidylinositol 345 trisphosphate 3 phosphatase, Platelet antigen BR, PTEN 1, PTEN1, Tensin homolog, TEP 1, TEP1, VLA 2 Receptor Alpha Subunit.
Background: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability.

基因ID

5728

UniProt

P60484

途径

TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling