RNF111 抗体 (AA 851-950) (Cy5)
Quick Overview for RNF111 抗体 (AA 851-950) (Cy5) (ABIN6984101)
抗原
See all RNF111 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 851-950
-
交叉反应
- 小鼠, 大鼠
-
预测反应
- Human,Dog,Cow,Sheep,Rabbit
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human RNF111
-
亚型
- IgG
-
-
-
-
应用备注
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
-
有效期
- 12 months
-
-
- RNF111 (Ring Finger Protein 111 (RNF111))
-
别名
- RNF111
-
背景
-
Synonyms: ARK, Arkadia, DKFZp313E0731, DKFZp686H1966, DKFZp761D081, E3 ubiquitin protein ligase Arkadia, FLJ38008, Ring finger protein 111, RNF 111, RN111_HUMAN.
Background: The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
-
基因ID
- 54778
-
UniProt
- Q6ZNA4
抗原
-