MICU1 抗体 (AA 1-250) (Biotin)
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北京 101111
Quick Overview for MICU1 抗体 (AA 1-250) (Biotin) (ABIN6983101)
抗原
See all MICU1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-250
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein G.
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免疫原
- Recombinant human CBARA1 Protein (1-250/476)
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亚型
- IgG
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anti-Mitochondrial Calcium Uptake 1 (MICU1) antibody
MICU1 适用: 人, 大鼠, 小鼠 WB, IHC (p), IF 宿主: 小鼠 Monoclonal unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) antibodyMICU1 适用: 人, 大鼠, 小鼠 WB, IHC (p), IF 宿主: 小鼠 Monoclonal 4E7 unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) antibodyMICU1 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) (AA 55-191) antibodyMICU1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) antibodyMICU1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) (AA 113-126) antibodyVerified MICU1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) antibodyMICU1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 小鼠 Monoclonal Mix unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) (AA 445-474), (C-Term) antibodyMICU1 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) (AA 380-478) antibodyMICU1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB 1:300-5000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))
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别名
- CBARA1/MICU1
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背景
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Synonyms: Mitochondrial Calcium Uptake 1, Calcium-Binding Atopy-Related Autoantigen 1, Atopy-Related Autoantigen CALC, Ara CALC, CBARA1, CALC, Calcium Binding Atopy-Related Autoantigen 1, Calcium Uptake Protein 1, Mitochondrial, Allergen Hom S 4, EFHA3, MPXPS, MICU1_HUMAN,
Background: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).
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基因ID
- 10367
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UniProt
- Q9BPX6
抗原
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